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Substrate
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Substrate UniProt AC: P02452
Substrate UniProt ID: CO1A1_HUMAN
Substrate symbol: COL1A1
Substrate name: Collagen alpha-1(I) chain
Substrate gene ID: 1277
Substrate species: Homo sapiens [9606]
Substrate UniProt entry: UniProtKB/Swiss-Prot


Cleaved by
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Protease	Cleavage site	P1-P1'	Provenance
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CTSK (P43235; CATK_HUMAN) Cathepsin K	DFSFLPQP	1200-1201	CutDB-ID:18371
BMP1 (P13497; BMP1_HUMAN) Bone morphogenetic protein 1	EGECCPVC	91-92	CutDB-ID:3064
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	GAPGAPGA	1049-1050	PubMed-ID:22367194
BMP1 (P13497; BMP1_HUMAN) Bone morphogenetic protein 1	GDTGPRGP	118-119	CutDB-ID:3065
CTSK (P43235; CATK_HUMAN) Cathepsin K	GLPGMKGH	263-264	MEROPS-ID:C01.036
CTSL (P07711; CATL1_HUMAN) Cathepsin L1	GPPGAPGP	194-195	MEROPS-ID:C01.032
CTSK (P43235; CATK_HUMAN) Cathepsin K	GPPGAPGP	194-195	MEROPS-ID:C01.036
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	GPPGLAGP	1004-1005	PubMed-ID:22367194
MMP1 (P03956; MMP1_HUMAN) Interstitial collagenase	GPQGIAGQ	953-954	BRENDA-EC:3.4.24.7
MMP2 (P08253; MMP2_HUMAN) 72 kDa type IV collagenase	GPQGIAGQ	953-954	MEROPS-ID:M10.003
MMP8 (P22894; MMP8_HUMAN) Neutrophil collagenase	GPQGIAGQ	953-954	CutDB-ID:16540
MMP13 (P45452; MMP13_HUMAN) Collagenase 3	GPQGIAGQ	953-954	CutDB-ID:18407
MMP14 (P50281; MMP14_HUMAN) Matrix metalloproteinase-14	GPQGIAGQ	953-954	CutDB-ID:16641
CTSL (P07711; CATL1_HUMAN) Cathepsin L1	GPRGLPGP	188-189	MEROPS-ID:C01.032
CTSS (P25774; CATS_HUMAN) Cathepsin S	GPVGARGP	1082-1083	PubMed-ID:25626674
CMA1 (P23946; CMA1_HUMAN) Chymase	LKSLSQQI	1238-1239	CutDB-ID:19533
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	LKSLSQQI	1238-1239	PubMed-ID:22367194
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	MGPPGLAG	1003-1004	PubMed-ID:22367194
CTSK (P43235; CATK_HUMAN) Cathepsin K	MGPSGPRG	184-185	MEROPS-ID:C01.036
ADAMTS2 (O95450; ATS2_HUMAN) A disintegrin and metalloproteinase with thrombospondin motifs 2	NFAPQLSY	161-162	UniProt-AC:P02452
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	PAGPTGPV	1074-1075	PubMed-ID:22367194
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	PGAPGAPG	1051-1052	PubMed-ID:22367194
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	PGLPGPSG	976-977	PubMed-ID:22367194
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	PGPMGPPG	1000-1001	PubMed-ID:22367194
CTSK (P43235; CATK_HUMAN) Cathepsin K	PGPMGPSG	181-182	MEROPS-ID:C01.036
CTSK (P43235; CATK_HUMAN) Cathepsin K	PGPQGFQG	199-200	MEROPS-ID:C01.036
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	PPGLAGPP	1005-1006	PubMed-ID:22367194
CTSS (P25774; CATS_HUMAN) Cathepsin S	PVGARGPA	1083-1084	PubMed-ID:25626674
CTSL (P07711; CATL1_HUMAN) Cathepsin L1	QGFQGPPG	202-203	MEROPS-ID:C01.032
CTSK (P43235; CATK_HUMAN) Cathepsin K	QPPQEKAH	1206-1207	CutDB-ID:18372
CTSK (P43235; CATK_HUMAN) Cathepsin K	SGLDGAKG	274-275	CutDB-ID:26952
CTSK (P43235; CATK_HUMAN) Cathepsin K	SGPRGLPG	187-188	CutDB-ID:26951
MMP25 (Q9NPA2; MMP25_HUMAN) Matrix metalloproteinase-25	TTLKSLSQ	1236-1237	PubMed-ID:22367194
BMP1 (P13497; BMP1_HUMAN) Bone morphogenetic protein 1	YYRADDAN	1218-1219	UniProt-AC:P02452