• Proteases search

    Autocomplete Tips

    Search for Proteases by
        – Gene symbol: MMP2
        – UniProt accession (UniProt AC): P08253
        – UniProt identifier (UniProt ID): MMP2_HUMAN
        – Protein name: 72 kDa type IV collagenase

            Troubleshooting: something goes wrong

  • Substrates search

    Autocomplete Tips

    Search for Substrates by
        – Gene symbol: ALB
        – UniProt accession (UniProt AC): P02768
        – UniProt identifier (UniProt ID): ALBU_HUMAN
        – Protein name: Serum albumin

            Troubleshooting: something goes wrong

  • Cleavage Site search

    Autocomplete Tips

    Search for amino acid sequence at cleavage site

    Examples of amino acid sequence at cleavage site:
        AVARLSQR
        CHGDLLEC

            Troubleshooting: something goes wrong

  • UniProt entries (Swiss-Prot and TrEMBL) search

    Autocomplete Tips

    Search for Protein by
        – Gene symbol: HIF1A
        – UniProt accession (UniProt AC): Q16665
        – UniProt identifier (UniProt ID): HIF1A_HUMAN
        – Protein name: Hypoxia-inducible factor 1-alpha

            Troubleshooting: something goes wrong

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Autocomplete will start after typing at least 2 characters.

Automatic suggestions for you query terms will appear in a list, you just have to select (mouse click) an item from the list.

If the autocomplete search returns too many results, only a few will be suggested to the user. So, you might need to carry on typing!

If the autocomplete search does not return any result, it might be because Proteasix Knowledge Base does not have information about the proteolytic cleavage. You can double check by browsing the complete list of proteases and substrates contained in the Proteasix Knowledge Base through the dedicated pages "Proteases" and "Substrates". Alternatively, try "Protein search".

Go to "Proteases" page

Go to "Substrates" page

Go to "Protein search"

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Autocomplete will start after typing at least 2 characters. Please be patient, there are more than 70 million UniProt (Swiss-Prot, TrEMBL) entries.

Automatic suggestions for you query terms will appear in a list, you just have to select (mouse click) an item from the list.

If the autocomplete search returns too many results, only a few will be suggested to the user. So, you might need to carry on typing!

If the autocomplete search does not return any result, it might be because the Proteasix Knowledge Base does not have information about this protein. Please note that UniProtKB secondary accession numbers are not included in the Proteasix Knowledge Base.

I got it!
 

Autocomplete will start after typing at least 2 characters.

Automatic suggestions for you query terms will appear in a list, you just have to select (mouse click) an item from the list.

If the autocomplete search returns too many results, only a few will be suggested to the user. So, you might need to carry on typing!

Cleavage occurs at the scissile bond between P1 and P1' residues (see FAQs section "What does P4, P3, P2, P1, P1', P2', P3', P4' mean?").

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